Qsymia clinical knowledge base

The scientific articles and other sources included in the Clinical Knowledge Base have been compiled and are presented by VIVUS for scientific and informational purposes only. Healthcare professionals should always refer to the current Full Prescribing Information for complete and up-to-date information on the approved indications for use and other relevant product information relating to Qsymia.

Weight Management with Phentermine/Topiramate MR

Phentermine/Topiramate MR has been extensively studied for weight management (obesity and overweight). This knowledge base provides access to various studies and journal articles.

Please note, VIVUS medications should only be prescribed in accordance with the therapeutic indications and use authorized in its Summary of Product Characteristics.

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VIVUS Pivotal Trials For Weight Management (4)

As an adjunct to a reduced-calorie diet and physical activity, Qsiva is indicated for weight management in adult patients with obesity and overweight with weight-related co-morbidities. Healthcare professionals should always refer to the current Summary of Product Characteristics for complete and up-to-date information on the approved indications for use and other relevant product information relating to Qsiva.

Controlled-Release Phentermine/Topiramate in Severely Obese Adults: A Randomized Controlled Trial (EQUIP)

Allison DB, Gadde KM, Garvey WT, Peterson CA, Schwiers ML, Najarian T, Tam PY, Troupin B, Day WW. Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP). Obesity (Silver Spring). 2012 Feb;20(2):330-42.

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Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER)

Gadde KM, Allison DB, Ryan DH, Peterson CA, Troupin B, Schwiers ML, Day WW. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet. 2011 Apr 16;377(9774):1341-52.

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Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL)

Garvey WT, Ryan DH, Look M, Gadde KM, Allison DB, Peterson CA, Schwiers M, Day WW, Bowden CH. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. Am J Clin Nutr. 2012 Feb;95(2):297-308.

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Effects of phentermine / topiramate extended-release, phentermine, and placebo on ambulatory blood pressure monitoring in adults with overweight or obesity: A randomized, multicenter, double-blind study

Bays HE, Hsia DS, Nguyen LT, Peterson CA, Varghese ST. Effects of phentermine / topiramate extended-release, phentermine, and placebo on ambulatory blood pressure monitoring in adults with overweight or obesity: A randomized, multicenter, double-blind study. Obes Pillars. 2024 Jan 8;9:100099.

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Qsymia clinical knowledge base

Weight Management with Phentermine/Topiramate MR

VIVUS Pivotal Trials For Weight Management (4)

Controlled-Release Phentermine/Topiramate in Severely Obese Adults: A Randomized Controlled Trial (EQUIP)

Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER)

Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL)

Effects of phentermine / topiramate extended-release, phentermine, and placebo on ambulatory blood pressure monitoring in adults with overweight or obesity: A randomized, multicenter, double-blind study

Cardiovascular Safety Profile In Weight-Management Treatment (1)

Cardiovascular effects of phentermine and topiramate: a new drug combination for the treatment of obesity

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